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KMID : 0861020180330060043
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Korea Journal of Herbology
2018 Volume.33 No. 6 p.43 ~ p.60
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Studies on Antioxidant and Anti-hyperlipidemic Effects in Induced Hypercholesterolemic Rats of Steamed Achyranthis Bidentatae Radix
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Kim Jeong-Soo
Park Myung-Jae
Kim Su-Ji
Shin Mi-Rae
Lee Ah-Reum
Park Hae-Jin
Roh Seong-Soo
Seo Young-Bae
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Abstract
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Objectives : This study was conducted to compare the effect of Achyranthis Bidentatae Radix on antioxidant changes and antihyperlipidemics in hypercholesterolemic rats according to changes in the number of steams.
Methods : The experimental animals were divided into six groups: normal (Nor), high cholesterol diet (Veh), high cholesterol diet with Simvastatin 5 ㎎/㎏ (Sim), high cholesterol diet with AR0 extract 200 ㎎/㎏ (AR0), high cholesterol diet with AR6 extract 200 ㎎/㎏ (AR6) and high cholesterol diet plus AR9 extract 200 ㎎/㎏ (AR9). I measured HDL, LDL TC, TG contents and ROS from each serums and compared them. I analyzed antioxidant- related protein expressions and cholesterol-related protein expressions in each liver tissues. I also performed optical microscopic analysis through liver tissue staining.
Results : The Antioxidant activity of Achyranthis Bidentatae Radix was increased by steaming processes. In vivo, AR0 decreased liver weight in hyperlipidemic rats. LDL TC, TG, AI and CRF were decreased but HDL was increased in AR0. AST, ALT, creatinine, and BUN were decreased in AR0. ROS was decreased in AR0, AR6, and AR9. SOD, catalase and GPx were decreased by steaming processes. p-AMPK was decreased but SREBP-2, p-ACC, and HMGCR were increased by steaming processes. Histologic analysis showed that AR0 decreased liver fat accumulation.
Conclusion : In conclusion, AR0 can be developed as a treatment for hyperlipemia. And it is required to research on antioxidant effect changes among different times steamed Achyranthis Bidentatae Radix.
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KEYWORD
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Achyranthis Bidentatae Radix, steaming process, antioxidant, anti-hyperlipide
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